
pUNO1-bTLR6
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Cat.code:
puno1-btlr6
- Documents
Expression-ready ORF Clones
Alias : TLR6, CD286
Toll Like Receptor 6
TLR6 is expressed in spleen and BPL and, similarly to TLR1, acts as a co-receptor. Studies with dominant negative receptors have shown that TLR6 cooperates with TLR2 to recognize peptidoglycan and the yeast cell wall particle, zymosan [1]. Furthermore, TLR6- and TLR2-deficient mice were reported to be hyporesponsive to mycoplasma macrophage-activating lipopeptide-2 kD (MALP-2), a diacylated lipoprotein, suggesting that TLR2 and TLR6 coordinate the response to this ligand. By contrast, TLR2 is able to recognize bacterial lipoproteins triacylated at the N-terminus cysteine residue [2]. Thus TLR6 appears to discriminate between the N-terminal lipoylated structures of MALP-2 and lipopeptides derived from other bacteria.
1. Ozinsky A. et al. (2000). Proc Natl Acad Sci U S A 97(25):13766-71.
2. Takeuchi O. et al. (2001). Int Immunol, 13(7):933-40.
Specifications
Bovine TLR6 (pUNO1-bTLR6)
ORF size : 2391 bp
Subclone : AgeI - NheI
Human TLR6 (pUNO1-hTLR6)
Genbank : NM_006068.4
ORF size : 2391 bp
Subclone : AgeI - NheI
Mouse TLR6, 795AA version (pUNO1-mTLR6b)
Genbank : NM_011604.5
ORF size : 2388 bp
Subclone : BspEI - NheI
Pig TLR6 (pUNO1-pTLR6)
Genbank : AB210286.1
ORF size : 2391 bp
Subclone : AgeI - NheI
Contents
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.
DOCUMENTS
Documents
Technical Data Sheet
Safety Data Sheet
Plasmid Map and Sequence
Plasmid Sequence
Certificate of analysis
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