TLR 6
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
|---|---|---|---|---|---|---|
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pUNO1-bTLR6 pUNO1 bearing the bovine TLR6 gene |
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20 µg |
puno1-btlr6
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pUNO1-hTLR6 pUNO1 bearing the human TLR6 gene |
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20 µg |
puno1-htlr6
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pUNO3-hTLR6 pUNO3 bearing the human TLR6 gene |
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20 µg |
puno3-htlr6
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pUNO1-mTLR6a pUNO1 bearing the mouse TLR6 gene, 806AA version |
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20 µg |
puno1-mtlr6
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pUNO1-mTLR6b pUNO1 bearing the mouse TLR6 gene, 795AA version |
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20 µg |
puno1-mtlr6b
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pUNO1-pTLR6 pUNO1 bearing the pig TLR6 gene |
Show product |
20 µg |
puno1-ptlr6
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Expression-ready ORF Clones
Alias : TLR6, CD286
Toll Like Receptor 6
TLR6 is expressed in spleen and BPL and, similarly to TLR1, acts as a co-receptor. Studies with dominant negative receptors have shown that TLR6 cooperates with TLR2 to recognize peptidoglycan and the yeast cell wall particle, zymosan [1]. Furthermore, TLR6- and TLR2-deficient mice were reported to be hyporesponsive to mycoplasma macrophage-activating lipopeptide-2 kD (MALP-2), a diacylated lipoprotein, suggesting that TLR2 and TLR6 coordinate the response to this ligand. By contrast, TLR2 is able to recognize bacterial lipoproteins triacylated at the N-terminus cysteine residue [2]. Thus TLR6 appears to discriminate between the N-terminal lipoylated structures of MALP-2 and lipopeptides derived from other bacteria.
1. Ozinsky A. et al. (2000). Proc Natl Acad Sci U S A 97(25):13766-71.
2. Takeuchi O. et al. (2001). Int Immunol, 13(7):933-40.
Specifications
Bovine TLR6 (pUNO1-bTLR6)
ORF size : 2391 bp
Subclone : AgeI - NheI
Human TLR6 (pUNO1-hTLR6)
Genbank : NM_006068.4
ORF size : 2391 bp
Subclone : AgeI - NheI
Human TLR6 (pUNO3-hTLR6)
ORF size : 2391 bp
Subclone : AgeI - NheI
Mouse TLR6, 806AA version (pUNO1-mTLR6)
Genbank : NM_011604.3
ORF size : 2421 bp
Subclone : NcoI - NheI
Mouse TLR6, 795AA version (pUNO1-mTLR6b)
Genbank : NM_011604.5
ORF size : 2388 bp
Subclone : BspEI - NheI
Pig TLR6 (pUNO1-pTLR6)
Genbank : AB210286.1
ORF size : 2391 bp
Subclone : AgeI - NheI
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pUNO-TLR Contents
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20 ̊C.
Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.
pUNO1 plamids:
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.
Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.
Avoid repeated freeze-thaw cycles.
pUNO3 plasmid:
- 20 µg of lyophilized DNA
- 1 ml Hygromycin B Gold (hygromycin) at 100 mg/ml
Hygromycin B is a hazardous compound. Avoid contact with skin and eyes.
Store Hygromycin B Gold at 4°C or -20˚C.
Avoid repeated freeze-thaw cycles.