TLR2-DN
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pUNO1-hTLR2-DN pUNO1 bearing the human TLR2-DN gene |
Show product |
20 µg |
puno1-htlr2-dn
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pUNO1-mTLR2-DN pUNO1 bearing the mouse TLR2-DN gene |
Show product |
20 µg |
puno1-mtlr2-dn
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Expression-ready ORF Clones
Alias : TLR2, CD282
TLR2-DN (ΔTIR) : Dominant Negative TIR-less TLR2 gene
TLR2 is involved in the recognition of multiple products of Gram-positive bacteria, mycobacteria and yeast. TLR2 has been shown to confer responsiveness to the lipopeptides present in LPS preparations.
However, it seems that some types of LPS can activate TLR2 [1]. TLR2 is known to heterodimerize with other TLRs, a property believed to extend the range of PAMPs that TLR2 can recognize.
TLR2 cooperates with TLR6 in the response to peptidoglycan [2] and diacylated mycoplasmal lipopeptide, and associates with TLR1 to recognize triacylated lipopetides. Furthermore, pathogen recognition by TLR2 is strongly enhanced by CD14.
TLR2-DN is a TIR-less form of the TLR2 gene generated by deleting the TIR domain (429 bp). This truncated gene is still able to recognize its ligands but is unable to induce the signaling cascade.
1. Netea MG. et al. (2002). Trends Immunol, 23(3):135-9.
Back to the topSpecifications
Human TLR2-DN (pUNO1-hTLR2-DN)
ORF size : 1926 bp
Subclone : AgeI - NheI
Mouse TLR2-DN (pUNO1-mTLR2-DN)
ORF size : 1920 bp
Subclone : AgeI - NheI
pUNO1 Contents
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.