ALPK1-TIFA: Sensing bacterial metabolites
InvivoGen offers a list of tools to study ALPK1 and TIFA signaling
Alpha protein Kinase 1 (ALPK1) and TRAF interacting forkhead-associated protein A (TIFA) form an important cytoplasmic surveillance pathway of pathogenic Gram-negative bacteria such as Shigella flexneri and Helicobacter pylori.
To foster research of ALPK1 and TIFA, InvivoGen provides a collection of tools to help answer the questions that surround this innate immune sensing pathway.
Choose from our collection
- ALPK1-TIFA Reporter cells
- ALPK1 ligand
- ALPK1 & TIFA genes, fully sequenced
Key features of InvivoGen's products
- Each lot is functionally tested
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Guaranteed free of unwanted bacterial contaminants
ALPK1 is a critical cytoplasmic alpha kinase responsible for the recognition and binding of bacterial sugar metabolites. Upon activation ALPK1 phosphorylates TIFA, inducing its oligomerization and the formation of 'TIFAsomes'. Ultimately, the ALPK1-TIFA signaling axis results in the initiation of an NF-κB dependent pro-inflammatory response. Targeting this pathway will be important in the development of novel treatments for modulating inflammation caused by bacterial infection as well as diseases associated with its dysregulation such as gastric cancer.