Engineered Fc pFUSE-Fc Vectors

Engineered Fc Region

Engineered pFUSE-Fc express mutant forms of the constant Fc regions of the human or murine IgG. They contain a multiple cloning site (MCS) upstream of these regions to enable the cloning of a gene of interest. Engineered Fc allow the production of IgG with modified effector function.
More info on Engineered Fc Regions

Products

Human
pFUSE-hIgG1e1-Fc		Fc-fusion protein expression plasmid - Engineered human IgG1, increased half-life
pFUSE-hIgG1e2-Fc		Fc-fusion protein expression plasmid - Engineered human IgG1, increased half-life
pFUSE-hIgG1e4-Fc		Fc-fusion protein expression plasmid - Engineered human IgG1, increased ADCC and CDC
pFUSE-hIgG1e5-Fc		Fc-fusion protein expression plasmid - Engineered human IgG1, increased ADCC
pFUSE-hIgG1e6-Fc		Fc-fusion protein expression plasmid - Engineered human IgG1, unchanged half-life
pFUSE-hIgG1e7-Fc		Fc-fusion protein expression plasmid - Engineered human IgG1, increased CDC
pFUSE-hIgG1e9-Fc		Fc-fusion protein expression plasmid - Engineered human IgG1, increased macrophage phagocytosis
pFUSE-hIgG1e11-Fc		Fc-fusion protein expression plasmid - Engineered human IgG1, increased half-life
pFUSE-hIgG1e12-Fc		Fc-fusion protein expression plasmid - Engineered human IgG1, increased half-life
pFUSE-hIgG1e13-Fc		Fc-fusion protein expression plasmid - Engineered human IgG1, decreased half-life
pFUSE-hIgG2e1-Fc		Fc-fusion protein expression plasmid - Engineered human IgG2, reduced CDC
pFUSE-hIgG4e1-Fc		Fc-fusion protein expression plasmid - Engineered human IgG4, reduced Fab-arm exchange
Mouse
pFUSE-mIgG1e2-Fc		Fc-fusion protein expression plasmid - Engineered murine IgG1, increased protein A affinity
pFUSE-mIgG2Ae1-Fc		Fc-fusion protein expression plasmid - Engineered murine IgG2a, reduced ADCC and CDC