pFUSE-hIgG1e12-Fc1
-
Cat.code:
pfc1-hg1e12
- Documents
ABOUT
pFUSE-hIgG1e12-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated M428L/N434A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e12-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Reference
Yeung Y.A. et al. Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates (2009) J. Immunol. 182: 7663-7671.
All products are for research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
In vitro transfection, Fc-fusion protein generation
In vitro transfection
Plasmid construct is confirmed by restriction analysis and full-length open reading frame (ORF) sequencing.
Mutations: M428L/N434A
Characteristics:
- Increased binding to neonatal FcR (FcRn)
- Increased half-life
CONTENTS
Contents
-
Product:pFUSE-hIgG1e12-Fc1
-
Cat code:pfc1-hg1e12
-
Quantity:20 µg
1 ml of Zeocin® (100 mg/ml)
Shipping & Storage
- Shipping method: Room temperature
- Upon receipt, store product at -20 °C.
Storage:
DOCUMENTS
Documents
Technical Data Sheet
Safety Data Sheet
Plasmid Sequence
Certificate of analysis
Need a CoA ?
