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pFUSE-hIgG1e12-Fc

Product Unit size Cat. code Docs. Qty. Price

pFUSE-hIgG1e12-Fc1

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20 µg

pfc1-hg1e12
+-
$684

pFUSE-hIgG1e12-Fc2

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20 µg

pfc2-hg1e12
+-
$684

pFUSE-hIgG1e12-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated M428L/N434A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.

pFUSE-hIgG1e12-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.

Yeung Y.A. et al. Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates (2009) J. Immunol. 182: 7663-7671.

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Specifications

Isotype: IgG1 human
Mutations:
M428L/N434A
Characteristics:
- Increased binding to neonatal FcR (FcRn)
- Increased half-life

Both plasmids are selectable with Zeocin™.

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pFUSE Contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin® (100 mg/ml)

room temperature Product is shipped at room temperature

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