pFUSE-hIgG4e1-Fc
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
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pFUSE-hIgG4e1-Fc1 Fc-fusion protein expression plasmid - Human IgG4e1 |
Show product |
20 µg |
pfc1-hg40e1
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pFUSE-hIgG4e1-Fc2 Fc-fusion protein expression plasmid - Human IgG4e1 with IL2ss |
Show product |
20 µg |
pfc2-hg40e1
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pFUSE-hIgG4e1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG4 heavy chain mutated S228P and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG4e1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Labrijn AF. et al., 2009. Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo. Nat Biotechnol. 27(8):767-71.
Back to the topSpecifications
Isotype : IgG4 human
Mutation: S228P
Characteristics:
- Reduced Fab-arm exchange
Both plasmids are selectable with Zeocin™.
Back to the toppFUSE Contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin® (100 mg/ml)
Product is shipped at room temperature