pFUSE-hIgG4e1-Fc1
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Cat.code:
pfc1-hg40e1
- Documents
ABOUT
pFUSE-hIgG4e1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG4 heavy chain mutated S228P and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG4e1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Labrijn AF. et al., 2009. Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo. Nat Biotechnol. 27(8):767-71.
All products are for internal research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
Plasmid construct has been confirmed by restriction analysis and sequencing. Plasmid DNA was purified by ion exchange chromatography and lyophilized.
CONTENTS
Contents
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Product:pFUSE-hIgG4e1-Fc1
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Cat code:pfc1-hg40e1
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Quantity:20 µg
1 ml of Zeocin® (100 mg/ml
Shipping & Storage
- Shipping method: Room temperature
- -20°C
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
DOCUMENTS
Documents
Safety Data Sheet
Technical Data Sheet
Certificate of analysis
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