STING Variants

STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS and ERIS) is essential for the TBK1-IRF3-dependent induction of IFN-β by microbial or self-DNA. It was recently found to act as a direct sensor of cyclic dinucleotides (CDNs). CDNs are important messengers in bacteria, affecting numerous responses of the prokaryotic cell, but also in mammalian cells acting as agonists of the innate immune response.

Several non-synonymous variants of STING have been described in the human population, as well as various induced mutants of the human and mouse STING genes. Studies have revealed that STING variation can affect CDN recognition and signal transduction.

InvivoGen provides most of the STING variants described, cloned and fully-sequenced into the expression plasmid pUNO1.

Products

STING-WT		human STING gene, "wild type"
STING-WT-HA		human STING gene, "wild type", HA-tagged
STING-S154		human STING gene, N154S variant
STING-M155		human STING gene, V155M variant
STING-A162		human STING gene, S162A variant
STING-N200		human STING gene, I200N variant
STING-A230		human STING gene, G230A variant
STING-H232		human STING gene, R232H variant
STING-HAQ		human STING gene, R71H-G230A-R293Q variant
STING-ß		human STING gene, isoform lacking exons 1-5
STING-MRP		human STING gene, isoform lacking exon 7
STING-Gt		mouse STING gene, I199N "Goldenticket (Gt)" variant