STING-A230
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
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pUNO1-hSTING-A230 pUNO1 bearing the human hSTING gene, G230A variant |
Show product |
20 µg |
puno1-hsting-a230
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Expression-ready ORF Clones
Human STING gene, G230A variant
STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS, and ERIS) is essential for the IFN response to microbial or self-DNA, and acts as a direct sensor of cyclic dinucleotides (CDNs), such as c-di-GMP.
CDNs are important messengers in bacteria, affecting numerous responses of the prokaryotic cell, but also in mammalian cells, acting as agonists of the innate immune response.
Several non-synonymous variants of STING have been described in the human population. Studies have shown that STING variation can affect CDN recognition and signal transduction. A230 contains a single amino acid substitution G232A. G230 is located in the flexible loop that forms a lid above the c-di-GMP binding pocket. The G230A variant is able to respond to lower concentrations of CDNs due to a different binding to the ligand [1].
1. Yi G. et al., 2013. Single nucleotide polymorphisms of human STING can affect Innate immune response to cyclic dinucleotides. PLoS One 8(10):e77846.
Back to the topSpecifications
Human STING-A230 (pUNO1-hSTING-A230)
ORF size : 1140 bp
Subclone : BspEI - NheI
pUNO1 Contents
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.