c-di-GMP
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Cat.code:
tlrl-nacdg
- Documents
ABOUT
STING Ligand. Bacterial cyclic di-nucleotide
Bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) is a second messenger produced in bacteria but not in mammals. This cyclic dinucleotide is involved in complex biological processes, such as biofilm formation, virulence and photosynthesis.
Besides its role as an intracellular and intercellular signaling molecule in prokaryotes, c-di-GMP also affects eukaryotes.
In mammals, c-di-GMP is recognized by STING, initiating a response characterized by the production of type I IFNs through the TBK1/IRF3 axis [1, 2]. The helicase DDX41 may play a role in the recognition of c-di-GMP upstream of STING [3].
Recent studies have also demonstrated that c-di-GMP exhibits potent adjuvant properties [4].
References
1. Jin L. et al., 2011. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 187(5):2595-601.
2. Burdette DL. et al., 2011. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 478(7370):515-8.
3. Parvatiyar K. et al., 2012 The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IFN immune response. Nat. Immunol.13(12):1155-61.
4. Madhun AS. et al., 2011. Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice. Vaccine.29(31):4973-82.
All products are for research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
C20H22N10O14P2 .2Na.
50 mg/ml in water
Biological activity assessed by measuring induction of IFN pathway using cellular assays, absence of endotoxins and other bacterial contaminants confirmed using HEK-Blue™ TLR4 and HEK-Blue™ TLR2 cells
CONTENTS
Contents
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Product:c-di-GMP
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Cat code:tlrl-nacdg
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Quantity:1 mg
1.5 ml endotoxin-free water
c-di-GMP is sterile filtered prior to lyophilization.
Shipping & Storage
- Shipping method: Room temperature
- -20 °C
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
DOCUMENTS
Documents
Technical Data Sheet
Validation Data Sheet
Safety Data Sheet
Certificate of analysis
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