Regulated Cell Death Modulators

Pyroptosis inhibitors

InvivoGen offers a collection of small molecules known to modulate the activity of key players involved in regulated cell death pathways.

Inhibitors of pyroptotic cell death

• Ac-YVAD-cmk
• VX-765
• Z-VAD-FMK

These molecules are inhibitors of the inflammatory caspases (Caspase-1, Caspase-11/4/5) responsible for the cleavage of Gasdermin-D (GSDMD) and the release of its N-terminal domain (NT), which features pore-forming functions at the plasma membrane. Accumulation of GSDMD pores at the plasma membrane allows the passage of soluble cytosolic contents and ions, and ultimately, leads to plasma membrane rupture.

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Modulators of necroptotic cell death

Necroptosis modulators

• BV6
• Necrostatin-1
• Z-IETD-FMK

These molecules target key players in TNF-induced necroptosis, the most studied and best-characterized necroptotic pathway.
Necrostatin-1 is a potent and selective inhibitor of the apoptosis and necroptosis initiator molecule RIPK1 (receptor-interacting serine/threonine-protein kinase 1). RIPK1-mediated cell death requires a loss/inhibition of cIAPs (cellular inhibitors of apoptosis proteins), which can be achieved using BV6, a specific antagonist of cIAPs. For full induction of necroptosis, concomitant blockade of the apoptosis initiator Caspase-8 is also required and can be achieved using Z-IETD-FMK.

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