STING Ligands

InvivoGen offers a growing collection of STING activators - Cyclic dinucleotides, xanthenone derivative, and diABZI

STING signaling pathway

The STimulator of INterferon Genes STING, alternatively known as MPYS, TMEM173, MITA, and ERIS, is a key sensor of cytosolic nucleic acids. Initially thought to serve solely as an adaptor protein for mediating signaling by cytosolic DNA sensors (CDS), STING was recently found to be a direct sensor of cyclic dinucleotides (CDNs).

CDNs are important messengers in bacteria affecting numerous responses of the prokaryotic cell. In mammalian cells, CDNs are potent inducers of the innate immune response. Even before the discovery of STING, CDNs had already been reported as bacterial messenger molecules and shown to exhibit anti-microbial, vaccine adjuvant, pro-DNA-replicative, and anti-cancer activities.

InvivoGen provides the most comprehensive choice of potent STING agonists. Our growing library includes.: 

• all four naturally occurring CDNs plus synthetic analogs - canonical (e.g. c-di-GMP) and non-canonical  (e.g. 2'3'-cGAMP) 
   
• diABZI - Non-nucleotide-based family member of small-molecule amidobenzimidazoles (ABZI)
   
• DMXAA - a synthetic analog of xanthenone
   
• Conjugatable STING ligands - antibody-drug conjugatable (ADCs) CDNs 

CDNs, the xanthenone derivative DMXAA, and diABZI have been found to bind and activate human and/or mouse STING, and ultimately lead to a potent type I IFN response.

The specificity, activity, and potency of each ligand are vigorously tested using our THP1-Dual™ reporter cell line collection. Moreover, each lot is functionally tested. For vaccination studies, InvivoGen supplies various ligands in a pre-clinical VacciGrade™ for in vivo studies.  

 Read our review on STING: Deciphering the STING Paradox