STING-S154
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
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pUNO1-hSTING-S154 pUNO1 bearing the human STING gene, N154S variant |
Show product |
20 µg |
puno1-hsting-s154
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Expression-ready ORF Clones
SAVI-associated N154S hSTING gene
STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS, and ERIS) is essential for the interferon (IFN) response to microbial or self DNA, and acts as a direct sensor of cyclic dinucleotides (CDNs) [1].
Several variants of STING have been described in the human population. The allele S154 contains a unique point mutation (N154S) in the “wild-type” R232-RGR hSTING variant.
This mutation confers gain-of-function and constitutive activation of STING with an upregulation of IFN production. It is associated with a chronic autoinflammatory disease, known as STING-associated vasculopathy with onset in infancy (SAVI) [2].
References:
1. Sun L. et al., 2013. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 339:786-91.
2. Liu Y. et al., 2014. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 371(6):507-18.
Specifications
Human STING-S154 (pUNO1-hSTING-S154)
ORF size : 1140 bp
Subclone : BspEI - NheI
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- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.