STING-M155

Expression-ready ORF Clones

SAVI-associated V155M hSTING gene

STING (stimulator of interferon genes; also known as TMEM173, MITA, MPYS, and ERIS) is essential for the interferon (IFN) response to microbial or self DNA, and acts as a direct sensor of cyclic dinucleotides (CDNs).

Several variants of STING have been described in the human population. The M155 (V155M) variant results in a gain-of- function mutation with the constitutive activation of STING and an upregulation of IFN production [1].

This mutation is associated with a chronic autoinflammatory disease, known as STING- associated vasculopathy with onset in infancy (SAVI) [2].

References:

1. Jeremiah N. et al., 2013. Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations. J Clin Invest. 124(12):5516-20.
2. Liu Y. et al., 2014. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 371(6):507-18.