pFUSE-hIgG1e9-Fc
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
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pFUSE-hIgG1e9-Fc1
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Show product |
20 µg |
pfc1-hg1e9
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pFUSE-hIgG1e9-Fc2
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Show product |
20 µg |
pfc2-hg1e9
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pFUSE-hIgG1e9-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated S239D/I332E/G236A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e9-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Richards JO,. et al., 2008. Optimization of antibody binding to FcgammaRIIa enhances macrophage phagocytosis of tumor cells. Mol Cancer Ther. 7(8):2517-27.
Back to the topSpecifications
Isotype: IgG1 human
Mutations: S239D/I332E/G236A
Characteristics:
- Increased FcγRIIa/FcγRIIb ratio
- Increased macrophage phagocytosis
Both plasmids are selectable with Zeocin™.
Back to the toppFUSE Contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin® (100 mg/ml)
Product is shipped at room temperature