pFUSE-hIgG1e6-Fc1
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Cat.code:
pfc1-hg1e6
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ABOUT
pFUSE-hIgG1e6-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated P257I/Q311I and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e5-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Reference
Datta-Mannan A. et al., 2007. Humanized IgG1 Variants with Differential Binding Properties to the Neonatal Fc Receptor: Relationship to Pharmacokinetics in Mice and Primates. Drug Metab. Dispos. 35: 86 - 94.
All products are for research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
In vitro transfection, Fc-fusion protein generation
In vitro transfection
Plasmid construct is confirmed by restriction analysis and full-length open reading frame (ORF) sequencing.
Mutations: P257I/Q311I
Characteristics:
- Increased binding to FcgRIIIA
- Unchanged half-life
CONTENTS
Contents
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Product:pFUSE-hIgG1e6-Fc1
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Cat code:pfc1-hg1e6
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Quantity:20 µg
1 ml of Zeocin® (100 mg/ml)
Shipping & Storage
- Shipping method: Room temperature
- Upon receipt, store product at -20 °C.
Storage:
DOCUMENTS
Documents
Technical Data Sheet
Safety Data Sheet
Plasmid Sequence
Certificate of analysis
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