TLR 2
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
|---|---|---|---|---|---|---|
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pUNO1-bTLR2 pUNO1 bearing the bovine TLR2 gene |
Show product |
20 µg |
puno1-btlr2
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pUNO1-hTLR2 pUNO1 bearing the human TLR2 gene |
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20 µg |
puno1-htlr2
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pUNO3-hTLR2 pUNO3 bearing the human TLR2 gene |
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20 µg |
puno3-htlr2
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pUNO1-mTLR2 pUNO1 bearing the mouse TLR2 gene |
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20 µg |
puno1-mtlr2
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pUNO1-pTLR2 pUNO1 bearing the pig TLR2 gene |
Show product |
20 µg |
puno1-ptlr2
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Expression-ready ORF Clones
Alias : TLR2, CD282
Toll Like Receptor 2
TLR2 is involved in the recognition of a wide array of microbial molecules. It recognizes peptidoglycan, lipoteichoic acid and lipoprotein from gram-positive bacteria, lipoarabinomannan from mycobacteria, and zymosan from yeast cell wall.
Moreover, TLR2 participates in the recognition of some types of LPS[1].
TLR2 is known to heterodimerize with other TLRs, a property believed to extend the range of microbial molecules that TLR2 can recognize. TLR2 cooperates with TLR6 in response to diacylated mycoplasmal lipopeptide, and associates with TLR1 to recognize triacylated lipopetides [2].
Furthermore, pathogen recognition by TLR2 is strongly enhanced by CD14 [3].
References:
1. Girard R et al., 2003. Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J Cell Sci. 116(Pt 2):293-302.
2. Ozinsky A. et al., 2000. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A. 97(25):13766-71.
3. Lotz S. et al., 2004. Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2. J Leukoc Biol. 75(3):467-77.
Specifications
Bovine TLR2 (pUNO1-bTLR2)
Genbank : NM_174197.2
ORF size : 2355 bp
Subclone : AgeI - NheI
Human TLR2 (pUNO1-hTLR2)
ORF size : 2355 bp
Subclone : AgeI - NheI
Human TLR2 (pUNO3-hTLR2)
ORF size : 2355 bp
Subclone : AgeI - NheI
Mouse TLR2 (pUNO1-mTLR2)
Genbank : AF216289.1
ORF size : 2355 bp
Subclone : AgeI - NheI
Pig TLR2 (pUNO1-pTLR2)
Genbank : AB208696.2
ORF size : 2358 bp
Subclone : AgeI - NheI
pUNO-TLR Contents
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20 ̊C.
Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.
pUNO1 plamids:
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.
Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.
Avoid repeated freeze-thaw cycles.
pUNO3 plasmid:
- 20 µg of lyophilized DNA
- 1 ml Hygromycin B Gold (hygromycin) at 100 mg/ml
Hygromycin B is a hazardous compound. Avoid contact with skin and eyes.
Store Hygromycin B Gold at 4°C or -20˚C.
Avoid repeated freeze-thaw cycles.