pUNO1-bTLR5
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Cat.code:
puno1-btlr5
- Documents
Expression-ready ORF Clones
Alias : TLR5, CD285
Toll Like Receptor 5
TLR5 is the Toll-like molecule that recognizes flagellin from both Gram-positive and Gram-negative bacteria. TLR5 was identified by the presence of the TIR domain and is expressed in spleen, peripheral blood leukocytes and epithelial cells.
Activation of the receptor stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88 and the serine kinase IRAK [1, 2]. TLR5 can generate a proinflammatory signal as a homodimer suggesting that it might be the only TLR required for flagellin recognition [2].
1. Gewirtz AT. et al. (2001). J Immunol, 167(4):1882-5.
2. Hayashi F. et al. (2001). Nature, 410(6832):1099-103.
Specifications
Bovine TLR5 (pUNO1-bTLR5)
ORF size : 2577 bp
Subclone : NcoI - NheI
Human TLR5 (pUNO1-hTLR5)
Genbank : NM_003268.6
ORF size : 2577 bp
Subclone : NcoI - NheI
Mouse TLR5 (pUNO1-mTLR5)
ORF size : 2580 bp
Subclone : AgeI - NheI
Pig TLR5 (pUNO1-pTLR5)
ORF size : 2571 bp
Subclone : AgeI - NheI
Contents
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.
DOCUMENTS
Documents
Technical Data Sheet
Safety Data Sheet
Plasmid Map and Sequence
Plasmid Sequence
Certificate of analysis
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