TLR1-DN
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
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pUNO1-hTLR1-DN pUNO1 bearing the human TLR1-DN gene |
Show product |
20 µg |
puno1-htlr1-dn
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pUNO1-mTLR1-DN pUNO1 bearing the mouse TLR1-DN gene |
Show product |
20 µg |
puno1-mtlr1-dn
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Expression-ready ORF Clones
Alias : TLR1, CD281
TLR1-DN (ΔTIR) : Dominant Negative TIR-less TLR1 gene
TLR1, the first member of the toll-like receptor family, was identified by the presence of a domain homology found in both Drosophila Toll and human interleukin-1 receptors.
TLR1 is expressed at higher levels in the spleen and peripheral blood cells [1]. No direct ligands have been identified so far for TLR1, and its function remains unclear. TLR1 seems to act as a coreceptor. TLR1 was shown to associate with TLR2 in response to triacylated lipopeptides [2], but not diacylated lipopeptides [3]. These observations suggest that TLR1 is able to discriminate among lipoproteins by recognizing the lipid configuration. TLR1-DN is a TIR-less form of the TLR1 gene generated by deleting the TIR domain (453 bp).
1. Zarember KA. & PJ. Godowski (2002). J Immunol, 168(2):554-61.
2. Takeuchi O. et al. (2002). J Immunol, 169(1):10-4.
3. Takeuchi O.et al. (2001). Int Immunol, 13(7):933-40.
Specifications
Human TLR1-DN (pUNO1-hTLR1-DN)
ORF size : 1908 bp
Subclone : AgeI - NheI
Mouse TLR1-DN (pUNO1-mTLR1-DN)
ORF size : 1917 bp
Subclone : AgeI - NheI
pUNO1 Contents
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.