TICAM2

Expression-ready ORF Clones

Alias: TRAM, TIRP

Toll like receptor adaptor molecule 2
TRIF-related adapter molecule

TICAM2

TRIF-related adaptor molecule (TRAM), also known as TIR-containing adaptor molecule (TICAM)-2, is an adaptor molecule involved in the MyD88-independent TLR4 signaling pathway [1]. In response to LPS stimulation, TICAM2 physically bridges TLR4 and TRIF transmitting LPS-induced signaling to TRIF which in turn activates IRF-3 and the production of interferon beta [2]. TICAM2 function is restricted to the TLR4 pathway, as TICAM2-deficient mice are defective in cytokine production in response to TLR4 ligand but not to other TLR ligands [3].

1. Fitzgerald KA. et al., 2003. LPS-TLR4 Signaling to IRF-3/7 and NF-{kappa}B Involves the Toll Adapters TRAM and TRIF. J Exp Med. 198(7):1043-1055
2. Oshiumi H. et al., 2003. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem. 278(50):49751-62
3. Yamamoto M. et al., 2003. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 4(11):1144-50