TLR 1
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
|---|---|---|---|---|---|---|
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pUNO1-bTLR1 pUNO1 bearing the bovine TLR1 gene |
Show product |
20 µg |
puno1-btlr1
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pUNO1-hTLR1 pUNO1 bearing the human TLR1 gene |
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20 µg |
puno1-htlr1
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pUNO3-hTLR1 pUNO3 bearing the human TLR1 gene |
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20 µg |
puno3-htlr1
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pUNO1-mTLR1 pUNO1 bearing the mouse TLR1 gene |
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20 µg |
puno1-mtlr1
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pUNO1-pTLR1 pUNO1 bearing the pig TLR1 gene |
Show product |
20 µg |
puno1-ptlr1
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Expression-ready ORF Clones
Alias : TLR1, CD281
Toll Like Receptor 1
TLR1 (Toll-Like Receptor 1), the first member of the toll-like receptor family, was identified by the presence of a domain homology found in both Drosophila Toll and human interleukin-1 receptors.
TLR1 is expressed at higher levels in the spleen and peripheral blood cells [1]. No direct ligands have been identified so far for TLR1, and its function remains unclear.
TLR1 seems to act as a coreceptor. TLR1 was shown to associate with TLR2 in response to triacylated lipopeptides [2], but not diacylated lipopeptides [3].
These observations suggest that TLR1 is able to discriminate among lipoproteins by recognizing the lipid configuration.
References:
1. Zarember KA. & PJ. Godowski (2002). J Immunol, 168(2):554-61.
2. Takeuchi O. et al. (2002). J Immunol, 169(1):10-4.
3. Takeuchi O.et al. (2001). Int Immunol, 13(7):933-40.
Specifications
Bovine TLR1 (pUNO1-bTLR1)
Genbank : FJ147090
ORF size : 2379 bp
Subclone : BspHI - NheI
Human TLR1 (pUNO1-hTLR1)
Genbank : NM_003263.3
ORF size : 2361 bp
Subclone : AgeI - NheI
Human TLR1 (pUNO3-hTLR1)
ORF size : 2361 bp
Subclone : AgeI - NheI
Mouse TLR1 (pUNO1-mTLR1)
Genbank : NM_030682.2
ORF size : 2388 bp
Subclone : BspHI - NheI
Pig TLR1 (pUNO1-pTLR1)
Genbank : AB210286
ORF size : 2391 bp
Subclone : BspHI - NheI
pUNO-TLR Contents
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20 ̊C.
Resuspended DNA should be stored at -20 ̊C and is stable up to 1 year.
pUNO1 plamids:
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Blasticidin is a harmful compound. Refer to safety data sheet for handling instructions.
Store blasticidin at 4°C or -20°C for up to two years. Product is stable 2 weeks at 37°C.
Avoid repeated freeze-thaw cycles.
pUNO3 plasmid:
- 20 µg of lyophilized DNA
- 1 ml Hygromycin B Gold (hygromycin) at 100 mg/ml
Hygromycin B is a hazardous compound. Avoid contact with skin and eyes.
Store Hygromycin B Gold at 4°C or -20˚C.
Avoid repeated freeze-thaw cycles.