TRAF6

Expression-ready ORF Clones

Alias: RNF85

TNF receptor associated factor 6.
TNF receptor-associated factor 6, E3 ubiquitin protein ligase.

Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) plays a key role in signal transduction of both the TNFR superfamily and the IL-1R/ TLR superfamily. TRAF6 functions as a ubiquitin ligase that mediates the activation of IKK [1]. It participates in both the MyD88-dependent and MyD88-independent signaling pathways induced by TLRs. Upon TLR stimulation TRAF6 interacts with IRAK-1 or TRIF leading to the activation of NF-kB [2,3].

References:

1. Deng L. et al., 2000. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103(2):351-61.
2. O’Neill LA., 2002. Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily. Curr Top Microbiol Immunol. 270:47-61.
3. Sato S. et al., 2003. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappaB and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol. 171(8):4304-10.