InvivoGen’s Reviews

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Innate immunity / PRR
RIG-I-Like Receptors (RLR) and Cytosolic DNA Sensors (CDS) pathways
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RIG-I-Like Receptors & Cytosolic DNA Sensors

RIG-I-like receptors (RLRs) constitute a family of cytoplasmic RNA helicases that are critical for...

Innate immunity / PRR
innate immune signaling pathways activated by PamadiFectin™ (CL553)
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Multi-TLR Agonists: Potential for Therapeutic Success

Toll-like receptors (TLRs) are the best studied pattern recognition receptors (PRRs) and their...

Innate immunity / PRR / STING
cGAS pathway
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cGAS - The long awaited cytosolic DNA sensor?

Cytosolic DNA is well-known to induce the production of type I interferons (IFNs) through the STING...

COVID-19
Spotlight on COVID-19: Vaccine development
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Spotlight on COVID-19: Vaccine development

The global vaccine effort in response to the COVID-19 pandemic is unprecedented in terms of both...

Innate immunity
TLR3 Pathway
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TLR3: racing for vaccine advantages

Toll-like receptors (TLRs) play a pivotal role in the initiation of prompt innate immune defenses...

Innate immunity / Inflammasome
Inflammasome-induced pyroptotic cell death
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Overview of Regulated Cell Death

Regulated cell death (RCD) is a lethal process taking place in the context of stressful stimuli (e.g...

COVID-19
Can immunity end the SARS-CoV-2 pandemic?
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Spotlight on COVID-19: Protective immunity & Re-infection

Learn more about the growing evidence that re-infection by SARS-CoV-2 can occur, with protective...

COVID-19
Spotlight on COVID-19: Predicated immune responses
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Spotlight on COVID-19: Predicted immune responses

Currently, there is very limited knowledge of the host immune response to SARS-CoV-2. However, based...

COVID-19
Spotlight on COVID-19: Treatment with repurposed drugs
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Spotlight on COVID-19: Treatment with repurposed drugs

Currently, there are no specific therapies approved for the treatment of coronavirus disease 2019...

COVID-19
The infection cycle of SARS-CoV-2
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Spotlight on COVID-19: Infection

COVID-19 is a pandemic that threatens global health. Its causative agent, SARS-CoV-2, a novel β...

Innate immunity
TLR7-TLR8 Pathway
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TLR7 & TLR8: fraternal twins

Toll-like receptors (TLRs) play a pivotal role in the initiation of anti-infectious immune responses...

Innate immunity / PRR / Inflammasome
NLRP3 Pathway
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NLRP3: a sophisticated drug target

NLRP3 is the best-described inflammasome sensor and an attractive drug target.

Innate immunity / PRR
RIGI Pathway
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RIG-I & cancer immunotherapy

The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer immunotherapy...

Antibodies
ADCC Pathway
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Immune Checkpoint Blockade: InestimAble Advances

Immune Checkpoint Anti-human Antibodies, ADCC Reporter Cell-Based Assay, Antibody Engineering

Innate immunity / PRR
Genomic Ahr
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AhR's key role in the intestinal microbiota and immunity

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcriptional factor widely expressed...

Antibodies / Vaccine & immunoglobulin
Effector fuctions of antibody isotypes
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Antibody Isotypes

Antibodies are immunoglobulin (Ig) molecules made up of 2 large heavy chains (~55 kDa each) and 2...

STING / Innate immunity / PRR
STING pathway
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Deciphering the STING Paradox

STING (stimulator of interferon genes), alternatively known as MPYS, TMEM173, MITA and ERIS, is a...

Innate immunity / PRR
Schematic representation of the Dectin-1 major isoforms
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β-Glucans: bittersweet ligands of Dectin-1

β-Glucans have been consumed for many centuries for their healing properties. Since the discovery of...