pDRIVE-LP
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
|---|---|---|---|---|---|---|
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pDRIVE-hLP pDRIVE bearing human LP promoter - LacZ |
Show product |
20 µg |
pdrive-hlp
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pDRIVE5SEAP-hLP pDRIVE bearing human LP promoter - SEAP |
Show product |
20 µg |
pdrive5s-hlp
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pDRIVE5Lucia-hLP pDRIVE bearing human LP promoter - Lucia |
Show product |
20 µg |
pdrive5lc-hlp
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L-plastin (LP) promoter in pDRIVE expression plasmid
L-plastin (LP) belongs to a family of genes that encode actin-binding proteins. LP is constitutively expressed at high levels in malignant epithelial cells but is not expressed in normal tissues, except at low levels in mature hematopoietic cells.
A 315-bp fragment of the 5’ region of the L-plastin gene, spanning the TATAAA box and a potential Sp1-binding site, is sufficient to exhibit strong promoter activity [1].
The L-plastin promoter driving the expression of a suicide gene was used to successfully inhibit the growth of ovarian tumor cells in vitro and in vivo [2].
References:
1. Lin CS. et al. 1993. Characterization of the human L-plastin gene promoter in normal and neoplastic cells. J Biol Chem 268(4):2793-801.
2. Peng XY et al. 2001. The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines. Cancer Res 61(11):4405-13.
Specifications
pDRIVE bearing human LP promoter - LacZ, SEAP or Lucia
Gene Promoter: L-Plastin (Lymphocyte cytosolic protein 1)
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™
pDRIVE contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperature
