pDRIVE-CXCR4
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
|---|---|---|---|---|---|---|
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pDRIVE-hCXCR4 pDRIVE bearing human CXCR4 promoter - LacZ |
Show product |
20 µg |
pdrive-hcxcr4
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pDRIVE5SEAP-hCXCR4 pDRIVE bearing human CXCR4 promoter - SEAP |
Show product |
20 µg |
pdrive5s-hcxcr4
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pDRIVE5Lucia-hCXCR4 pDRIVE bearing human CXCR4 promoter - Lucia |
Show product |
20 µg |
pdrive5lc-hcxcr4
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CXCR4 promoter in pDRIVE expression plasmid
CXCR4 is the receptor for the chemokine SDF1 and a coreceptor for HIV-1 entry. The expression of CXCR4 is upregulated in many types of cancers but low in the liver and other major organs. The CXCR4 promoter contains a TATAbox, a nuclear respiratory factor-1 (NRF-1) site, and for GC boxes [1].
A 279 bp fragment of the CXCR4 promoter was shown to have a “tumor-on” status in vitro and in vivo particularly in melanoma and breast cancers [2].
References:
1. Moriuchi M. et al., 1997. Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry. J Immunol. 159(9):4322-9.
2. Zhu ZB. et al., 2004. Transcriptional targeting of adenoviral vector through the CXCR4 tumor-specific promoter. Gene Ther. 11(7):645-8.
Specifications
pDRIVE bearing human CXCR4 promoter - LacZ, SEAP or Lucia
Gene Promoter: CXC-Chemokine receptor 4
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™
pDRIVE contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperature
