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pDRIVE-COX-2

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-hCOX2

pDRIVE bearing human COX-2 promoter - LacZ

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20 µg

pdrive-hcox2
+-
$554

pDRIVE5SEAP-hCOX2

pDRIVE bearing human COX-2 promoter - SEAP

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20 µg

pdrive5s-hcox2
+-
$554

pDRIVE5Lucia-hCOX2

pDRIVE bearing human COX-2 promoter - Lucia

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20 µg

pdrive5lc-hcox2
+-
$554

pDRIVE-mCOX2

pDRIVE bearing mouse COX-2 promoter - LacZ

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20 µg

pdrive-mcox2
+-
$554

pDRIVE5SEAP-mCOX2

pDRIVE bearing mouse COX-2 promoter - SEAP

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20 µg

pdrive5s-mcox2
+-
$554

pDRIVE5Lucia-mCOX2

pDRIVE bearing mouse COX-2 promoter - Lucia

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20 µg

pdrive5lc-mcox2
+-
$554

COX-2 promoter in pDRIVE expression plasmid

COX-2 is an inducible isoform of cyclooxygenase. The expression of COX-2 is undetectable under physiological conditions but up-regulated in many malignant tumors.

COX-2, which is a PKC-dependent gene, is important for the genesis of cancer. COX-2 promoter contains a cAMP response element and sites for AP-2 and NF-κB that are both PKC-responsive cis-elements.

COX-2 promoter has been used to target gene expression in pancreatic [1], gastrointestinal [2] and ovarian cancers. Similar levels of expression of luciferase and HSVtk genes were obtained with COX-2 and CMV promoters.

 

References:

1. Wesseling JG et al. 2001. Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma. Cancer Gene Ther 8(12):990-6.
2. Yamamoto M et al. 2001. Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy ofgastrointestinal cancers. Mol Ther. 3(3):385-94.

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Specifications

pDRIVE bearing human COX-2 promoter - LacZ, SEAP or Lucia
Gene Promoter: Cyclo-oxygenase 2 isoform
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™

pDRIVE bearing mouse COX-2 promoter - LacZ, SEAP or Lucia
Gene: Cyclo-oxygenase 2 isoform
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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