pDRIVE-CD43
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
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pDRIVE-hCD43 pDRIVE bearing human CD43 promoter - LacZ |
Show product |
20 µg |
pdrive-hcd43
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pDRIVE5SEAP-hCD43 pDRIVE bearing human CD43 promoter - SEAP |
Show product |
20 µg |
pdrive5s-hcd43
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pDRIVE5Lucia-hCD43 pDRIVE bearing human CD43 promoter - Lucia |
Show product |
20 µg |
pdrive5lc-hcd43
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CD43 promoter (Leukocytes & platelets) in pDRIVE expression plasmid
CD43, a major sialoglycoprotein expressed on the surface of leukocytes and platelets, plays an important role both in adhesion and signal transduction.
The CD43 promoter does not contain any TATA or CAAT boxes, but is highly enriched in G and C nucleotides and contains short repeat sequences similar to those found in promoters of "housekeeping" genes [1].
Transcription from the CD43 promoter is mediated by the transcription factor Sp1, which binds to repeats of a GGGTGG motif in the 5'-flanking sequence.
This regulatory region is ubiquitously functional in mammalian cells, providing a high transcriptional potential [2].
References:
1. Shelley CS. et al. 1990. Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins. Biochem J. 270(3):569-76.
2. Kudo S. & Fukuda M. 1995. Tissue-specific transcriptional regulation of human leukosialin (CD43) gene is achieved by DNA methylation. Biol Chem 270(22):13298-302.
Specifications
pDRIVE bearing human CD43 promoter - LacZ, SEAP or Lucia
Gene Promoter: Leukosialin, sialophorin
Specificity: Leukocytes & platelets
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™
Back to the toppDRIVE contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperature
