pDRIVE-CD14
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
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pDRIVE-hCD14 pDRIVE bearing human CD14 promoter - LacZ |
Show product |
20 µg |
pdrive-hcd14
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pDRIVE5SEAP-hCD14 pDRIVE bearing human CD14 promoter - SEAP |
Show product |
20 µg |
pdrive5s-hcd14
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pDRIVE5Lucia-hCD14 pDRIVE bearing human CD14 promoter - Lucia |
Show product |
20 µg |
pdrive5lc-hcd14
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CD14 promoter (Monocytic cells) in pDRIVE expression plasmid
CD14 is a receptor for bacterial lipopolysaccharide expressed on the surface of myeloid-derived cells, and is strongly upregulated during monocytic cell differentiation.
Monocyte-specific expression of CD14 is regulated at the transcriptional level.
The CD14 promoter contains a C/EBP [1] and Sp1 [2] site that are critical for tissue-specific regulation of CD14 gene expression.
References:
1. Pan Z. et al. 1999. CCAAT/enhancer-binding protein activates the CD14 promoter and mediates transforming growth factor beta signaling in monocyte development. J Biol Chem 274(33):23242-8.
2. Park S. et al. 2002. Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter. Mol Immunol 39(1-2):25.
Specifications
pDRIVE bearing human CD14 promoter - LacZ, SEAP or Lucia
Gene Promoter: Monocyte Receptor for Bacterial LPS
Specificity: Monocytic cells
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™
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pDRIVE contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperature