pDRIVE-hE2F1
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Cat.code:
pdrive-he2f1
- Documents
ABOUT
E2F promoter in pDRIVE expression plasmid
E2F transcription factors are critical regulators of cell growth and are often overexpressed in cancer cells because of the frequent aberrations in the pRb/E2F/p16(INK4a) pathway.
E2F-1 is a transcription factor that activates its own transcription and that of other genes involved in the G(1) to S transition phase of the cell cycle.
The E2F-1 promoter was used in adenovirus to drive the expression of the E1A adenoviral gene and induced selective killing in a variety of tumor cell lines [1].
References:
1. Tsukuda K. et al. 2002. An E2F-responsive replication-selective adenovirus targeted to the defective cell cycle in cancer cells: potent antitumoral efficacy but no toxicity to normal cell. Cancer Res 62(12):3438-47.
All products are for internal research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
in vitro or in vivo transfection
Tumor
in vitro transfection
Plasmid construct has been confirmed by restriction analysis and full-length ORF sequencing.
CONTENTS
Contents
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Product:pDRIVE-hE2F1
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Cat code:pdrive-he2f1
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Quantity:20 µg
1 ml of Zeocin® (100 mg/ml)
Shipping & Storage
- Shipping method: Room temperature
- -20°C
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
DOCUMENTS
Documents
Technical Data Sheet
Plasmid Map and Sequence
Safety Data Sheet
Certificate of analysis
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