Human IL-18 Antibody - Camoteskimab Biosimilar

Human IgG1 Fc silent - CAS #2492472-82-7

ABOUT

Anti-human IL-18 - Camoteskimab biosimilar - CAS #2492472-82-7

Anti-hIL-18-hIgG1-FES is a biosimilar antibody of Camoteskimab, a human interleukin 18 (IL-18) antibody that inhibits IL-18 signaling. This monoclonal antibody (mAb) is currently under investigation for the treatment of atopic dermatitis and adult-onset Still's disease.

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Anti-hIL-18-hIgG1-FES comprises the variable region of Camoteskimab and the effectorless IgG1 constant region of Camoteskimab harboring a triple mutation L242F/L243E/P339S (FES).

This mAb can be used together with HEK-Blue™ IL-18 cells for screening and neutralization assays to inhibit IL-18 signaling induced by recombinant human IL-18 (see figure).

 

Key features

  • Each lot is functionally tested and validated.
  • The complete sequence of the antibody construct was verified.
  • The absence of endotoxins is determined using the EndotoxDetect™ assay.

 

If you are interested in the corresponding isotype control Anti-β-Gal-hIgG1-FES mAb, please contact us.

All products are for research use only, and not for human or veterinary use.

Binding of anti-IL-18 mAb
Binding of anti-IL-18 mAb

SPECIFICATIONS

Specifications

Target

IL-18

Target species

Human

Species
Human
Isotype
hIgG1
kappa
Recommended isotype control
Human IgG1 Isotype Control Antibody
Clone
Camoteskimab
CAS number
2492472-82-7
Synonyms
MEDI 2338
CERC-007
AEVI-007
AVTX-007
Molecular weight
146.4 kDa
Tag
Tag-free
Source
CHO cells
Purification
Protein A
Formulation buffer

Sodium phosphate buffer with glycine, saccharose, and stabilizing agents

Preservative
Azide-free
Purity
≥ 95%
Appearance (form)
Lyophilized
Reconstitution buffer
Sterile water (not provided)
Endotoxin

Negative (tested using EndotoxDetect™ assay)

Tested applications

Neutralization assay, ELISA

Quality control

Each lot is functionally tested and validated.

CONTENTS

Contents

  • Product: 
    Anti-hIL-18-hIgG1-FES
  • Cat code: 
    hil18-mab16
  • Quantity: 
    100 µg

Shipping & Storage

  • Shipping method:  Room temperature

    • Storage:

    • -20 °C
    Stability: -20 °C for up to 1 year

    Caution:

    • Avoid repeated freeze-thaw cycles

Details

Camoteskimab and IL-18 background

Camoteskimab is a fully human monoclonal antibody (mAb) designed to target interleukin 18 (IL-18) and block the IL-18 signaling [1]. Camoteskimab features a triple mutation L242F/L243E/P339S in its IgG1 constant region for low effector functions [2].

IL-18, formerly called interferon-γ (IFN-γ) inducing factor, is a pro-inflammatory cytokine that causes a variety of biological effects associated with infection, inflammation, and autoimmune processes [3]. It is a powerful inducer of type 1 responses mediated by activated NK, Th1, and CD8+ cytotoxic T cells [4]. 

Camoteskimab is under investigation for the treatment of Adult-Onset Still's Disease [1,4] and atopic dermatitis [NCT06436183].

 

References:

1. Bindoli S, et al., 2024. Adult-Onset Still's Disease (AOSD): Advances in Understanding Pathophysiology, Genetics and Emerging Treatment Options. Drugs. 84(3):257-274.
2. https://go.drugbank.com/drugs/DB18876
3. Dinarello CA. et al., 1998. Overview of interleukin-18: more than an interferon-gamma inducing factor. J Leukoc Biol. 63(6):658-64.
4. Baggio C, et al., 2023. IL-18 in Autoinflammatory Diseases: Focus on Adult Onset Still Disease and Macrophages Activation Syndrome. Int J Mol Sci.24(13):11125.
5. https://clinicaltrials.gov/study/NCT06436183

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