Recombinant human IL-18 protein - Bioactive cytokine

Human IL-18 protein - E. coli -expressed, tag-free, with HSA

Recombinant human IL-18 is a high-quality and biologically active cytokine, validated using proprietary IL-18 reporter cells. This member of the IL-1/TLR cytokine superfamily is produced in E. coli and thoroughly purified to remove endotoxins.

Recombinant human IL-18 can be used together with HEK-Blue™ IL-18 cells for the screening of inhibitory molecules, such as Camoteskimab, a monoclonal antibody targeting IL-18 (see figures).

Key features

• Each lot is validated using HEK-Blue™ IL-18 cells
• Endotoxin < 10 EU/mg
• 0.2 µm sterile-filtered

Applications

• Standard for IL-18 detection and quantification assays
• Screening and release assays for antibodies blocking IL-18 signaling
• Screening and release assays for engineered IL-18

Interleukin 18 (IL-18) is a pro-inflammatory cytokine and a powerful inducer of type 1 responses mediated by activated NK, Th1, and CD8+ cytotoxic T cells. Abnormal IL-18 serum concentration is associated with immune-mediated inflammation diseases, including cryopyrin-associated periodic syndrome (CAPS), familial mediterranean fever (FMF), and multiple sclerosis.