pDRIVE-SV40 / hAlb
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
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pDRIVE-SV40-hAlb pDRIVE bearing human SV40 / hAlb promoter - LacZ |
Show product |
20 µg |
pdrive-sv40halb
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pDRIVE5SEAP-SV40-hAlb pDRIVE bearing human SV40 / hAlb promoter - SEAP |
Show product |
20 µg |
pdrive5s-sv40halb
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pDRIVE5Lucia-SV40-hAlb pDRIVE bearing human SV40 / hAlb promoter - Lucia |
Show product |
20 µg |
pdrive5lc-sv40halb
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SV40 / hAlb promoter (Liver) in pDRIVE expression plasmid
The albumin gene is transcribed at very high levels in fetal liver and, unlike the adjacent AFP gene, remains active after birth. A small segment of the bovine albumin 5’flanking region, from -170 to +20, is sufficient for promoter activity and specificity [1].
This segment contains the CCAAT box, TATA box and the binding site of HNF1, a liver specific transcription factor.
The albumin promoter is a liver-specific promoter. It can drive the expression of a transgene, such as HSV-tk, specifically in hepatocellular carcinoma cells eliminating the risk of systemic toxicity of GCV [2].
References:
1. Power SC. et al. 1994. Isolation and functional analysis of the promoter of the bovine serum albumin gene. Biochem Biophys Res Com 203(3):1447-1456.
2. Kuriyama S. et al. 1997. Tissue-specific expression of HSV-tk gene can induce efficient antitumor effect and protective immunity to wild-type hepatocellular carcinoma. Int J Cancer. 71(3):470-5.
Specifications
pDRIVE bearing human SV40 / hAlb promoter - LacZ, SEAP or Lucia
Gene Promoter: Alb: Albumin
Specificity: Liver
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™
Back to the toppDRIVE contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperature
