pDRIVE-FerL
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
|---|---|---|---|---|---|---|
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pDRIVE-hFerL pDRIVE bearing human FerL promoter - LacZ |
Show product |
20 µg |
pdrive-hferl
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pDRIVE5SEAP-hFerL pDRIVE bearing human FerL promoter - SEAP |
Show product |
20 µg |
pdrive5s-hferl
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pDRIVE5Lucia-hFerL pDRIVE bearing human FerL promoter - Lucia |
Show product |
20 µg |
pdrive5lc-hferl
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FerL promoter (Ubiquitous) in pDRIVE expression plasmid
Ferritin is a ubiquitous iron storage protein, whose major role is to sequester and detoxify intracellular iron that has not been utilized in cellular metabolism.
Ferritin is a 24 subunit protein composed of two subunit types, termed H (heavy) and L (light), which perform complementary functions in the protein.
The H subunit plays a role in the rapid detoxification of iron whereas the L subunit facilitates long-term iron storage. The synthesis of ferritin is highly regulated by the iron status of the cell.
The iron regulation is achieved at the translational level through interaction between a 28-nucleotide iron-responsive element (IRE), located in the 5’ untranslated region (5’UTR) of ferritin mRNAs, and a cytosolic protein, the iron regulatory protein [1, 2].
References:
1. Eisenstein RS & Munro HN. 1990. Translational regulation of ferritin synthesis by iron. Enzyme 44(1-4):42-58.
2. Bevilacqua MA et al. 1992. Promoter for the human ferritin heavy chain-encoding gene (FERH): structural and functional characterization. Gene 15;111(2):255-60.
Specifications
pDRIVE bearing human FerL promoter - LacZ, SEAP or Lucia
Gene Promoter: Ferritin Light Chain
Specificity: Ubiquitous
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™
Back to the toppDRIVE contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperature
