pBOOST2 wtIRF1
| Product | Unit size | Cat. code | Docs. | Price | |
|---|---|---|---|---|---|
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pBOOST2-wthIRF1 pBOOST2 Human Wild-type IRF-1 |
Show product |
20 µg |
pbst2-wthirf1
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pBOOST2-wtmIRF1 pBOOST2 Murine Wild-type IRF-1 |
Show product |
20 µg |
pbst2-wtmirf1
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Genetic adjuvants for DNA vaccines with wild-type IRF1 genes | Increase Th2 response
pBOOST2-wtIRF1 plasmids express the human or murine wild-type interferon regulatory factor 1 (IRF-1) gene. IRF-1 has been described to primarily increase Th2 antibody responses [1].
Following intramuscular or gene gun injections of DNA vaccines, IRF-1 can increase the titers of antibodies up to 10-fold.
pBOOST2-wtIRF1 plasmids express the transgene under the control of the strong and ubiquitous EF-1α/HTLV composite promoter and are selectable in E. coli with Zeocin™.
Reference:
1. Sasaki S. et al., 2002. Regulation of DNA-raised immune responses by cotransfected interferon regulatory factors. J Virol.76(13):6652-9.
Back to the topSpecifications
Gene: wild-type IRF-1 gene
Species: Human or Murine
Backbone: pBOOST2
Selection: Zeocin
Th2 polarization
Back to the topContents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperature
