MPLA Synthetic - TLR4 Agonist

TLR4 Agonist - Synthetic monophosphoryl lipid A

Synthetic lipid A from E. coli (MPLAs) is a monophosphoryl lipid A with 6 fatty acyl groups. It is structurally very similar to natural MPLA except that natural MPLA contains a mixture of 5, 6, and 7 acyl lipid A. The number of fatty acids is a major determinant of the immunogenicity of endotoxin.

Synthetic E. coli lipid A activates TLR4 but does not activate TLR2 even at high concentrations reflecting its high purity.