Recombinant human BAFF/TNFSF13B/BLyS protein - Bioactive cytokine

Human BAFF protein - Mammalian cell-expressed, tag-free, carrier-free

Recombinant human BAFF is a high-quality and biologically active cytokine, validated using proprietary BAFF-R, BCMA, and TACI reporter cells. This member of the TNF superfamily is produced in CHO cells to ensure protein glycosylation and bona fide 3D structure.

Recombinant human BAFF can be used together with HEK-Blue™ BAFF-R,  HEK-Blue™ BCMA, or HEK-Blue™ TACI cells for the screening of inhibitory molecules, such as Belimumab, a monoclonal antibody targeting BAFF (see figures).

Key features

• Each lot is validated using HEK-Blue™ BCMA cells
• Endotoxin ≤ 0.001 EU/µg
• 0.2 µm sterile-filtered

Applications

• Standard for BAFF detection and quantification assays
• Screening and release assays for antibodies blocking BAFF signaling
• Screening and release assays for engineered BAFF

B-cell activation factor (BAFF), also called TNFSF13B or BLyS, is a cytokine from the tumor necrosis factor superfamily. Together with A proliferation-inducing ligand (APRIL, aka TNFSF13), BAFF plays a prominent role in B cell differentiation, proliferation, survival, and functional responses.

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