Recombinant human APRIL
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Cat.code:
rcyc-hapril-hsNEW
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ABOUT
Human APRIL protein - Mammalian cell-expressed, His-Flag-tag, carrier-free
Recombinant human APRIL is a high-quality and biologically active cytokine, validated using proprietary BAFF-R, BCMA, and TACI reporter cells. This member of the TNF superfamily is produced in HEK293 cells to ensure protein glycosylation and bona fide 3D structure.
Recombinant human APRIL can be used together with HEK-Blue™ BCMA, or HEK-Blue™ TACI cells for the screening of inhibitory molecules, such as Sibeprenlimab, a monoclonal antibody targeting APRIL (see figures).
Key features
- Each lot is validated using HEK-Blue™ BCMA cells
- Endotoxin ≤ 1 EU/µg
- 0.2 µm sterile-filtered
Applications
- Standard for APRIL detection and quantification assays
- Screening and release assays for antibodies blocking APRIL signaling
- Screening and release assays for engineered APRIL
A proliferation-inducing ligand (APRIL), also called TNFSF13, is a cytokine from the tumor necrosis factor superfamily. Together with B-cell activation factor (BAFF, aka TNFSF13B), APRIL plays a prominent role in B cell differentiation, proliferation, survival, and functional responses.
All InvivoGen products are for internal research use only, and not for human or veterinary use.
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SPECIFICATIONS
Specifications
O75888-1
100 μg/ml in water
Phosphate buffer saline (pH 7.4), 8% trehalose
0.2 µm filtration
The absence of bacterial contamination (e.g. lipoproteins and endotoxins) has been confirmed using HEK-Blue™ TLR2 and HEK‑Blue™ TLR4 cells.
Cellular assays (tested), ELISA
Each lot is functionally tested and validated.
CONTENTS
Contents
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Product:Recombinant human APRIL
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Cat code:rcyc-hapril-hs
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Quantity:10 µg
Shipping & Storage
- Shipping method: Room temperature
- -20°C
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
DOCUMENTS
Documents
Technical Data Sheet
Validation Data Sheet
Safety Data Sheet
Certificate of analysis
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