CFA
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Cat.code:
vac-cfa-10
- Documents
ABOUT
Vaccine Adjuvant: Complete Freund’s Adjuvant
Complete Freund's Adjuvant (CFA) consists of heat-killed Mycobacterium tuberculosis in non-metabolizable oils (paraffin oil and mannide monooleate). CFA contains trehalose 6,6’ dimycolate (TDM), which stimulates Mincle. Additionally, CFA has ligands for TLR2, TLR4, and TLR9.
CFA can be used to produce water-in-oil emulsions of antigens.
Injection of antigen in CFA induces a Th1-dominated response when compared to injection in Incomplete Freund's Adjuvant (IFA), which lacks mycobacterial components and induces a Th2-dominated response.
An essential outcome of the CFA-mediated response is an intense inflammatory reaction at the site of antigen deposition. For most applications, CFA is usually only necessary for the initial immunization, while IFA is the adjuvant of choice for subsequent immunizations.
CFA is VacciGrade™, a high-quality pre-clinical grade.
All products are for research use only, and not for human or veterinary use.
VacciGrade™
VacciGrade™ is a high-quality pre-clinical grade. VacciGrade™ products are filter-sterilized (0.2 µm) and filled under strict aseptic conditions in a clean room*. The absence of bacterial contamination is assessed by a sterility test using a pharmacopeia-derived assay. The level of bacterial contaminants (endotoxins and lipoproteins) in each lot is verified using a LAL assay and/or a TLR2 and TLR4 reporter assay.
*Except for LPS VacciGrade™, which is prepared in a laminar flow hood dedicated to LPS.
SPECIFICATIONS
Specifications
Vaccination
heat killed Mycobacterium tuberculosis (strain H37Ra), Mannide Monooleate, Paraffin oil
Sterility guaranteed
Each lot is validated using physico-chemical methods.
CONTENTS
Contents
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Product:CFA
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Cat code:vac-cfa-10
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Quantity:10 ml
Shipping & Storage
- Shipping method: Room temperature
- 4°C
- Do not freeze
Storage:
Caution:
DOCUMENTS
Documents
Technical Data Sheet
Safety Data Sheet
Certificate of analysis
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