Anti-β-Gal monoclonal antibody for ADC
Product | Unit size | Cat. code | Docs. | Qty. | Price | |
---|---|---|---|---|---|---|
Anti-β-Gal-hIgG1* β-galactosidase antibody (isotype control) for conjugation assays - Human IgG1 |
Show product |
1 mg |
bgal-mab1-1
|
|
Monoclonal human IgG1 antibody against β-galactosidase for antibody-drug conjugation
InvivoGen provides Anti-β-Gal-hIgG1*, a monoclonal antibody (mAb) specifically developed for the generation of control antibody-drug conjugates (ADCs). This mAb features:
- the variable region of a murine mAb which specifically targets the E. coli β-galactosidase (β-Gal),
- a human IgG1 constant region that displays high effector functions, including antibody-dependent cell-mediated cytotoxicity (ADCC), and complement-dependent cytotoxicity (CDC).
InvivoGen's Anti-β-Gal-hIgG1* has been generated by recombinant DNA technology, produced in CHO cells, and purified by affinity chromatography.
Key features of Anti-β-Gal-hIgG1*:
- No binding to any other antigen than β-Gal, as verified by ELISA, flow cytometry, and ADC-based cellular assays
- Human IgG1 constant region for high effector functions
- The absence of bacterial contamination has been confirmed
Application for Anti-β-Gal-hIgG1*:
-
Negative control for ADC-based assays
InvivoGen offers Anti-HER2-IgG1 and Anti-TROP2-hIgG1 specific mAbs, as well as conjugatable PRR ligands for building immunostimulatory ADCs.
You may choose from TLR7 and STING agonists:
- Conjugatable TLR7 agonists: TL7-887 and TL7-975
- Conjugatable STING agonists: STG-982 and STG-968
Learn more about bioconjugation
InvivoGen’s products are for research use only, and not for clinical or veterinary use.
Back to the top
Specifications
Specificity: Targets E. coli β-galactosidase
Isotype: Human IgG1, Kappa
Source: Chinese hamster ovary (CHO) cells
Formulation: 0.2 μm filtered solution in 150 mM sodium chloride, 20 mM sodium phosphate buffer with 5% saccharose
Purification: Affinity chromatography with protein A
Tested Applications: Flow cytometry, ELISA, Antibody-drug conjugation
Quality control:
- The binding of Anti-β-Gal-hIgG1* to β-galactosidase has been validated using ELISA.
- The absence of non-specific binding of Anti-β-Gal-hIgG1* has been validated using flow cytometry and antibody-drug conjugate (ADC)-based cellular assays.
- The complete sequence of the antibody has been verified.
- The absence of bacterial contamination (e.g. lipoproteins and endotoxins) has been confirmed using HEK-Blue™ hTLR2 and HEK-Blue™ TLR4 cellular assays.
Contents
- 1 mg of purified Anti-β-Gal-hIgG1* monoclonal antibody (mAb), provided azide-free and lyophilized
The product is shipped at room temperature.
Store lyophilized antibody at -20 °C.
Lyophilized product is stable for at least 1 year. Reconstituted antibody is stable for 1 month at 4°C and for 1 year at -20°C. Avoid repeated freeze-thaw cycles.
Back to the top