TDB
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Cat.code:
tlrl-tdb
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ABOUT
Mincle Agonist - Synthetic analog of the cord factor
Trehalose-6,6-dibehenate (TDB) is a synthetic analog of trehalose-6,6-dimycolate (TDM, also known as cord factor), which is the most studied immunostimulatory component of Mycobacterium tuberculosis [1].
TDB binds the C-Type lectin Mincle (macrophage-inducible C-type lectin) [1,2]. Upon TDB recognition Mincle interacts with the Fc receptor common γ-chain (FcRγ), which triggers intracellular signaling through Syk leading to CARD9-dependent NF-κB activation.
References:
1. Ishikawa, E. et al., 2009. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J. Exp. Med. 206, 2879–2888.
2. Schoenen, H. et al., 2010. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J. Immunol. 184, 2756–2760.
All products are for research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
C56H106O13
1 - 100 µg/ml
CONTENTS
Contents
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Product:TDB
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Cat code:tlrl-tdb
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Quantity:2 mg
Shipping & Storage
- Shipping method: Room temperature
- -20 °C
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
Details
Chemical structure of TDB:
DOCUMENTS
Documents
Technical Data Sheet
Safety Data Sheet
Certificate of analysis
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