TDB - Mincle Agonist

Synthetic analog of the cord factor

ABOUT

Mincle Agonist - Synthetic analog of the cord factor

Trehalose-6,6-dibehenate (TDB) is a synthetic analog of trehalose-6,6-dimycolate (TDM, also known as cord factor), which is the most studied immunostimulatory component of Mycobacterium tuberculosis [1].

TDB binds the C-Type lectin Mincle (macrophage-inducible C-type lectin) [1,2]. Upon TDB recognition Mincle interacts with the Fc receptor common γ-chain (FcRγ), which triggers intracellular signaling through Syk leading to CARD9-dependent NF-κB activation.

 

References:

1. Ishikawa, E. et al., 2009. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J. Exp. Med. 206, 2879–2888.
2. Schoenen, H. et al., 2010. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J. Immunol. 184, 2756–2760.

All products are for research use only, and not for human or veterinary use.

SPECIFICATIONS

Specifications

Source
Synthetic
CAS number
66758-35-8
Chemical formula

C56H106O13

Molecular weight
987.43 g/mol
Working concentration

1 - 100 µg/ml

CONTENTS

Contents

  • Product: 
    TDB
  • Cat code: 
    tlrl-tdb
  • Quantity: 
    2 mg

Shipping & Storage

  • Shipping method:  Room temperature
  • Storage:

    • -20 °C

    Caution:

    • Avoid repeated freeze-thaw cycles

Details

Chemical structure of TDB:

TDB chemical structure

DOCUMENTS

Documents

TDB

Technical Data Sheet

Safety Data Sheet

Certificate of analysis

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