SIGIRR

Expression-ready ORF Clones

Alias : TIR8

Single ImmunoGlobulin IL-IR-Related molecule.

Single Ig IL-1R-related molecule (SIGIRR), also called TIR8, is a member of the Toll/IL-1 receptor (TIR) superfamily. SIGGIR is mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut [1]. It contains the typical conserved motifs that characterize the TIR superfamily, but is structurally and functionally distinct [2]. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice and cells from SIGIRR-deficient mice show enhanced activation in response to either IL-1 or certain TLR ligands [3]. These data suggest that SIGIRR functions as an important modulator of TLR/IL-1R signaling.

1. Polentarutti N. et al., 2003. Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. Eur Cytokine Netw. 14(4):211-8.
2. Thomassen E. et al., 1999. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine. 11(6):389-99.
3. Wald D. et al., 2003. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4(9):920-7.

Specifications

Human SIGIRR (pUNO1-hSIGIRR)

Genbank : NM_021805.2
ORF size : 1233 bp
Subclone : AgeI - NheI

Mouse SIGIRR (pUNO1-mSIGIRR)

Genbank : NM_023059.3
ORF size : 1230 bp
Subclone : NcoI - EcoRI

pUNO1 Contents

• 20 µg of lyophilized DNA
• 2 x 1 ml blasticidin at 10 mg/ml

Product is shipped at room temperature.

Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.

Resuspended DNA should be stored at -20°C and is stable for up to 1 year.

Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.