RIPK2

Expression-ready ORF Clones

Alias : RICK, CARD3, RIP2, CARDIAK

Receptor interacting serine/threonine kinase 2.
Caspase recruitment domain-containing protein 3.

Receptor-interacting protein 2 (RIP2), also known as RICK, Rip2, CARDIAK and CARD3, is a serine/threonine kinase characterized by a C-terminal caspase activation and recruitment domain (CARD). Beside caspase activation, RIP2 is implicated in NF-kB activation. It acts as a signal transducer for pattern-recognition receptors, including TLRs and NODs [1-4]. RIP2 is recruited to certain TLR-signaling complexes after ligand stimulation promoting the activation of NF-kB and the production of proinflammatory cytokines. Furthermore, RIP2 is required for optimal TCR signalling and T-cell differentiation [1]. Thus RIP2 is an essential mediator for both the innate and adaptive immune responses.

References:

1. Kobayashi K. et al., 2002. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416(6877):194-9.
2. Chin AI. et al., 2002. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416(6877):190-4.
3. Pauleau AL. & Murray PJ., 2003. Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol. 23(21):7531-9.
4. Girardin SE. et al., 2001. CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.EMBO Rep.2(8):736-42.

Specifications

Human RIPK2 (pUNO1-hRIPK2)

Genbank : NM_003821.5
ORF size : 1623 bp
Subclone : AgeI - NheI

Mouse RIPK2 (pUNO1-mRIPK2)

Genbank : NM_138952.3
ORF size : 1620 bp
Subclone : AgeI - NheI

pUNO1 Contents

• 20 µg of lyophilized DNA
• 2 x 1 ml blasticidin at 10 mg/ml

Product is shipped at room temperature.

Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.

Resuspended DNA should be stored at -20°C and is stable for up to 1 year.

Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.