NOD1

Expression-ready ORF Clones

Alias : NLRC1, CARD4

Nucleotide-binding oligomerization domain containing 1 (NOD1)
Caspase recruitment domain-containing protein 4

Nucleotide-binding oligomerization domain 1 (NOD1), also called caspase-recruitment domain (CARD)-4, is an intracellular pathogen-recognition molecule expressed ubiquitously in adult tissues. Upon bacterial invasion, NOD1 induces NF-κB activation pathways [1]. NOD1 recognizes a naturally occurring muropeptide of peptidoglycan (PGN) that presents a unique amino acid at its terminus called diaminopilemic acid (DAP) [2].
This amino acid is found mainly in the PGN of gram-negative bacteria designating NOD1 as a sensor of gram-negative bacteria. Recent studies show that signaling through NOD1 is able to activate NF-κB in cells infected with gram-negative bacteria that can bypass TLR activation [3].

References:

1. Inohara N. et al., 1999. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem. 274(21):14560-7.
2. Girardin SE. et al., 2003. Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science. 300(5625):1584-7.
3. Kim JG. et al., 2004. Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors. Infect Immun. 72(3):1487-95.