LY86

Expression-ready ORF Clones

Alias : MD1

Lymphocyte antigen 86.
Myeloid differentiation factor 1.

MD-1 (LY86) was identified by immunoprecipitation as a molecule that physically associates with RP105. Stable expression of MD-1 was shown to induce an increase in cell surface RP105 on a cell line that expresses RP105 alone, suggesting that MD-1 is important for efficient cell surface expression of RP105 [1]. Similarly to the TLR4/MD2 complex, the RP105/MD1 complex is involved in LPS response leading to LPS-induced B-cell proliferation, antibody production, and B7.2/CD86 up-regulation [2]. MD-1 plays also a role in the regulation of allogeneic and xenogeneic skin graft survival[3].

1. Miyake K. et al., 1998. Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. J Immunol, 161(3):1348-53.
2. Nagai Y. et al., 2002. Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. Blood, 99(5):1699-705.
3. Hadidi S. & Gorczynski RM., 2004. MD-1 expression regulates direct and indirect allorecognition. Tissue Antigens. 63(2):132-41.