PMA
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Cat.code:
tlrl-pma
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ABOUT
Phorbol myristate acetate. NF-κB Activator
Phorbol 12-myristate 13-acetate (PMA), also known as 12-O-tetradecanoylphorbol 13-acetate (TPA), is a specific activator of Protein Kinase C (PKC) and hence activates nuclear factor-kappa B (NF-κB). NF-κB is a transcription factor that regulates numerous physiological functions and is involved in the pathogenesis of various diseases. It has been identified as a potential therapeutic target in inflammatory processes, cancer, and autoimmune diseases[1].
PMA is the most common and potent phorbol ester. It is active at nanomolar concentrations and activates NF-κB in a dose-dependent manner [1]. PMA causes a wide range of effects in cells and tissues and is a very potent mouse skin tumor promoter [2, 3].
InvivoGen’s PMA is designed to study the NF-κB pathway in cellular assays.
Key Features of PMA:
- Potent activator of NF-κB in vitro
- Each lot of PMA is highly pure (≥98%) and functionally tested
References:
1. Hellweg C.E. et al., 2006. Activation of nuclear factor kappa B by different agents: influence of culture conditions in a cell-based assay. Ann N Y Acad Sci. 1091:191-204.
2. Chang MS. et al., 2005. Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways. Cell Signal. 17(3):299-310.
3. Fürstenberger G. et al., 1981. Skin tumor promotion by phorbol esters is a two-stage process. PNAS. 78(12):7722-6.
All products are for research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
In vitro cellular assays
C36H56O8
5 mg/ml in DMSO
10 ng - 1 µg/ml
Each lot is functionally tested and validated.
CONTENTS
Contents
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Product:PMA
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Cat code:tlrl-pma
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Quantity:5 mg
1.5 ml of sterile endotoxin-free water
PMA is provided as a translucent film
Shipping & Storage
- Shipping method: Room temperature
- -20°C
- Avoid repeated freeze-thaw cycles
- Protect from light
Storage:
Caution:
DOCUMENTS
Documents
Technical Data Sheet
Validation Data Sheet
Safety Data Sheet
Certificate of analysis
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