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pDRIVE-Elastase-1

Product Unit size Cat. code Docs. Qty. Price

pDRIVE-rElastase

pDRIVE bearing rat Elastase-1 promoter - LacZ

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20 µg

pdrive-relastase1
+-
$554

pDRIVE5SEAP-rElastase

pDRIVE bearing rat Elastase-1 promoter - SEAP

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20 µg

pdrive5s-relastase1
+-
$554

pDRIVE5Lucia-rElastase

pDRIVE bearing rat Elastase-1 promoter - Lucia

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20 µg

pdrive5lc-relastase1
+-
$554

Elastase-1 promoter (Pancreatic acinar cells) in pDRIVE expression plasmid

The elastase gene is one of the pancreatic digestive enzyme genes which is activated in a stage- and site- specific manner during development of the mammalian gut.

The rat elastase 1 promoter is a 213 bp fragment comprised of the core promoter (-72 to +8) and the enhancer (-205 to -73).

The elastase 1 promoter was shown to direct the expression of a human growth hormone transgene in pancreatic acinar cells, stomach, duodenum, and colon.

This pattern of selective expression limited to the gastroenteropancreatic organ system is specified by the A element, one of three functional elements in the elastase 1 enhancer.

 

References:

1. Ornitz DM. et al. 1985. Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature 313(6003):600-2.
2. Rose SD. et al. 1994. A single element of the elastase I enhancer is sufficient to direct transcription selectively to the pancreas and gut. Mol Cell Biol 14(3):2048-57.

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Specifications

pDRIVE bearing rat Elastase-1 promoter - LacZ, SEAP or Lucia

Gene Promoter: Elastase-1

Specificity: Pancreatic acinar cells

Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia

Selection: Zeocin™

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pDRIVE contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin™ (100 mg/ml)

room temperature Product is shipped at room temperature

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