pDRIVE-Elastase-1
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
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pDRIVE-rElastase pDRIVE bearing rat Elastase-1 promoter - LacZ |
Show product |
20 µg |
pdrive-relastase1
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pDRIVE5SEAP-rElastase pDRIVE bearing rat Elastase-1 promoter - SEAP |
Show product |
20 µg |
pdrive5s-relastase1
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pDRIVE5Lucia-rElastase pDRIVE bearing rat Elastase-1 promoter - Lucia |
Show product |
20 µg |
pdrive5lc-relastase1
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Elastase-1 promoter (Pancreatic acinar cells) in pDRIVE expression plasmid
The elastase gene is one of the pancreatic digestive enzyme genes which is activated in a stage- and site- specific manner during development of the mammalian gut.
The rat elastase 1 promoter is a 213 bp fragment comprised of the core promoter (-72 to +8) and the enhancer (-205 to -73).
The elastase 1 promoter was shown to direct the expression of a human growth hormone transgene in pancreatic acinar cells, stomach, duodenum, and colon.
This pattern of selective expression limited to the gastroenteropancreatic organ system is specified by the A element, one of three functional elements in the elastase 1 enhancer.
References:
1. Ornitz DM. et al. 1985. Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature 313(6003):600-2.
2. Rose SD. et al. 1994. A single element of the elastase I enhancer is sufficient to direct transcription selectively to the pancreas and gut. Mol Cell Biol 14(3):2048-57.
Specifications
pDRIVE bearing rat Elastase-1 promoter - LacZ, SEAP or Lucia
Gene Promoter: Elastase-1
Specificity: Pancreatic acinar cells
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™
Back to the toppDRIVE contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperature
