pDRIVE-CD68

CD68 promoter (Macrophages) in pDRIVE expression plasmid

Murine macrosialin and its human homolog CD68 are heavily glycosylated transmembrane proteins expressed specifically in macrophages and macrophage-related cells.

The CD68 gene promoter directs macrophage-specific expression. Although the promoter lacks a classical TATA box, it contains other protein binding sites consistent with preferential monocyte/macrophage gene expression1.

CD68 promoter has been used to achieve constitutive expression of IL-10 specifically in macrophages [2].

References:

1. Jiang Z. et al. 1998. Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein. Genomics 50(2):199-205.
2. Lang R.et al. 2002. Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter. J Immunol. 168(7):3402-11.