pDRIVE-CD68
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
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pDRIVE-hCD68 pDRIVE bearing human CD68 promoter - LacZ |
Show product |
20 µg |
pdrive-hcd68
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pDRIVE5SEAP-hCD68 pDRIVE bearing human CD68 promoter - SEAP |
Show product |
20 µg |
pdrive5s-hcd68
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pDRIVE5Lucia-hCD68 pDRIVE bearing human CD68 promoter - Lucia |
Show product |
20 µg |
pdrive5lc-hcd68
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pDRIVE-mCD68 pDRIVE bearing mouse CD68 promoter - LacZ |
Show product |
20 µg |
pdrive-mcd68
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pDRIVE5SEAP-mCD68 pDRIVE bearing mouse CD68 promoter - SEAP |
Show product |
20 µg |
pdrive5s-mcd68
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pDRIVE5Lucia-mCD68 pDRIVE bearing mouse CD68 promoter - Lucia |
Show product |
20 µg |
pdrive5lc-mcd68
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CD68 promoter (Macrophages) in pDRIVE expression plasmid
Murine macrosialin and its human homolog CD68 are heavily glycosylated transmembrane proteins expressed specifically in macrophages and macrophage-related cells.
The CD68 gene promoter directs macrophage-specific expression. Although the promoter lacks a classical TATA box, it contains other protein binding sites consistent with preferential monocyte/macrophage gene expression1.
CD68 promoter has been used to achieve constitutive expression of IL-10 specifically in macrophages [2].
References:
1. Jiang Z. et al. 1998. Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein. Genomics 50(2):199-205.
2. Lang R.et al. 2002. Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter. J Immunol. 168(7):3402-11.
Specifications
pDRIVE bearing human CD68 promoter - LacZ, SEAP or Lucia
Gene Promoter: Homolog of Macrosialin
Specificity: Macrophages
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™
pDRIVE bearing mouse CD68 promoter - LacZ, SEAP or Lucia
Gene: Homolog of Macrosialin
Specificity: Macrophages
Backbone: pDRIVE, pDRIVE5-SEAP or pDRIVE5-Lucia
Selection: Zeocin™
Back to the toppDRIVE contents
- 20 µg of lyophilized DNA
- 1 ml of Zeocin™ (100 mg/ml)
Product is shipped at room temperature
