CLEC 7Ab - Dectin-1
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pUNO1-bCLEC7Ab pUNO1 bearing the bovine CLEC7A (DECTIN1) gene, isoform_2 |
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20 µg |
puno1-bclec7ab
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pUNO1-hCLEC7Ab pUNO1 bearing the human CLEC7A (DECTIN1) gene, isoform_2 (major variant B) |
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20 µg |
puno1-hclec7ab
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pUNO1-mCLEC7Ab pUNO1 bearing the mouse CLEC7A (DECTIN1) gene, isoform_2 (in RAW cell lines) |
Show product |
20 µg |
puno1-mclec7ab
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Expression-ready ORF Clones
Alias : CLEC7A, DECTIN1, CLECSF12, CD369, SCARE2
Dectin-1.
C-type lectin domain family 7, member A
C-type lectin-like receptor superfamily 12B
Dectin-1 is a C-type lectin expressed on phagocytic cells, including macrophages and neutrophils, that recognizes and responds to live fungal pathogens.
Dectin-1 mediates both the internalization and cellular responses to beta-glucan containing particles such as Zymosan, a cell wall preparation of Saccharomyces cerevisiae, through unique mechanisms [1]. Zymosan is also recognized by TLR2/TLR6 heterodimers which signaling mediates the activation of NF-kB and the production of inflammatory cytokines. Recent data suggest that Dectin-1 and TLR2/TLR6 signaling combine to enhance the responses triggered by each receptor [2,3].
1. Herre J. et al., 2004. The role of dectin-1 in antifungal immunity. Crit Rev Immunol. 24(3):193-204.
2. Gantner BN. et al., 2003. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J.Exp. Med. 197(9):1107-17.
3. Mukhopadhyay S. et al., 2004. The potential for Toll-like receptors to collaborate with other innate immune receptors. Immunology.112(4):521-30.
Specifications
Bovine CLEC7A isoform 2 (pUNO1-bCLEC7Ab)
ORF size : 606 bp
Subclone : AgeI - NheI
Human CLEC7A isoform 2 (major variant B) (pUNO1-hCLEC7Ab)
Genbank : NM_022570.4
ORF size : 606 bp
Subclone : AgeI - NheI
Mouse CLEC7A isoform 2 (pUNO1-mCLEC7Ab)
ORF size : 600 bp
Subclone : BspHI - NheI
pUNO1 Contents
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.