CLEC 7Ab - Dectin-1

Expression-ready ORF Clones

Alias : CLEC7A, DECTIN1, CLECSF12, CD369, SCARE2

Dectin-1.
C-type lectin domain family 7, member A
C-type lectin-like receptor superfamily 12B

Dectin-1 is a C-type lectin expressed on phagocytic cells, including macrophages and neutrophils, that recognizes and responds to live fungal pathogens.
Dectin-1 mediates both the internalization and cellular responses to beta-glucan containing particles such as Zymosan, a cell wall preparation of Saccharomyces cerevisiae, through unique mechanisms [1]. Zymosan is also recognized by TLR2/TLR6 heterodimers which signaling mediates the activation of NF-kB and the production of inflammatory cytokines. Recent data suggest that Dectin-1 and TLR2/TLR6 signaling combine to enhance the responses triggered by each receptor [2,3].

1. Herre J. et al., 2004. The role of dectin-1 in antifungal immunity. Crit Rev Immunol. 24(3):193-204.
2. Gantner BN. et al., 2003. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J.Exp. Med. 197(9):1107-17.
3. Mukhopadhyay S. et al., 2004. The potential for Toll-like receptors to collaborate with other innate immune receptors. Immunology.112(4):521-30.