PGLYRP3
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
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pUNO1-hPGLYRP3 pUNO1 bearing the human PGLYRP3 (PGRPIA) gene |
Show product |
20 µg |
puno1-hpglyrp3
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Expression-ready ORF Clones
Alias : PGRPIA
Peptidoglycan recognition protein 3.
Peptidoglycan Recognition Protein I α.
Peptidoglycan recognition proteins (PGRPs) are pattern recognition molecules that are conserved from insects to mammals and recognize bacteria and their unique cell wall component, peptidoglycan (PGN) [1]. However, the consequences of this recognition are unknown, except in insects where PGRPs trigger the expression of antimicrobial peptides [2]. Four mammalian PGRPs have been identified, PGRP-L, -S, -Ialpha, and -Ibeta, that are selectively expressed in different organs and have little homology outside the PGRP domains [3]. This diversity suggests that binding of PGN to each PGRP may produce a different biological effect.
1. Dziarski R., 2004. Peptidoglycan recognition proteins (PGRPs). Mol Immunol. 40(12):877-86.
2. Takehana A. et al., 2002. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc Natl Acad Sci U S A.99(21):13705-10.
3. Liu C. et al., 2001. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.J Biol Chem. 276(37):34686-94.
Specifications
Human PGLYRP3 (pUNO1-hPGLYRP3)
Genbank : NM_052891.2
ORF size : 1026 bp
Subclone : AgeI - NheI
pUNO1 Contents
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.