MRT67307 - TBK1/IKKε Inhibitor

InvitroFit™ PRR inhibitor

ABOUT

TBK1/IKKε inhibitor

MRT67307 is a potent, reversible kinase inhibitor specifically blocking the function of TBK1 (TANK-binding kinase 1) and I-kappa-B kinase (IKK) epsilon (IKKε, or IKBKE), thereby preventing the phosphorylation of IRF3 (interferon regulatory factor 3) and subsequent expression of interferon-stimulated genes (ISGs) [1]. Unlike BX795 from which it is derived, MRT67307 has no noted effect on the canonical IKKs, IKKα, or IKKβ, that are involved in the activation of NF-κB [1]. Additionally, MRT67307 is a highly potent inhibitor of ULK1, a key component of the autophagy pathway [2].

Key features:

  • MRT67307 potently inhibits IRF signaling in a dose-dependent manner.
  • MRT67307 does not affect NF-κB signaling.
  • InvitroFit™ grade: each lot is highly pure (≥95%) and functionally tested.


References:

1. Clark, K. et al., 2011. Novel cross-talk within the IKK family controls innate immunity. Biochem J 434, 93-104.
2. Petherick, K.J. et al., 2015. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem 290, 11376-11383.

All products are for research use only, and not for human or veterinary use.

InvitroFit™

InvitroFit™ is a high-quality standard specifically adapted for in vitro studies of inhibitors. InvitroFit™ products are highly pure (≥95%) and guaranteed free of bacterial contamination, as confirmed using HEK Blue™ TLR2 and HEK Blue™ TLR4 cellular assays. Each lot is rigorously tested for functional activity using validated (or proprietary) cellular models. This grade ensures reliability and reproducibility for your research applications.

SPECIFICATIONS

Specifications

CAS number
1190378-57-4
Chemical formula

C26H36N6O2 . x HCl

Molecular weight
464.60 g/mol
Purity
≥ 95% (UHPLC)
Solubility

15 mg/ml in H2O

Working concentration

1 µM to 20 μM for cell culture assays

Endotoxin

Negative (tested using EndotoxDetect™ assay)

Tested applications

In vitro cellular assays

Quality control

Each lot is functionally tested and validated using cellular assays.

CONTENTS

Contents

  • Product: 
    MRT67307
  • Cat code: 
    inh-mrt
  • Quantity: 
    10 mg

Shipping & Storage

  • Shipping method:  Room temperature
  • Storage:

    • -20 °C
    Stability: The reconstituted product is stable at least 3 months at -20 °C.

    Caution:

    • Avoid repeated freeze-thaw cycles

Details

Chemical structure of MRT67307:

Chemical structure of MRT67307

DOCUMENTS

Documents

MRT67307

Technical Data Sheet

Validation Data Sheet

Safety Data Sheet

Certificate of analysis

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CUSTOMER SERVICE & TECHNICAL SUPPORT

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