LBP
| Product | Unit size | Cat. code | Docs. | Qty. | Price | |
|---|---|---|---|---|---|---|
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pUNO1-hLBP pUNO1 bearing the human LBP gene |
Show product |
20 µg |
puno1-hlbp
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pUNO1-mLBP pUNO1 bearing the mouse LBP gene |
Show product |
20 µg |
puno1-mlbp
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Expression-ready ORF Clones
Alias : BPIFD2
Lipopolysaccharide-binding protein (LBP) is a serum glycoprotein synthesized in the liver [1]. LBP binds to a variety of lipopolysaccharides (LPS) and to lipid A, the lipid moiety of LPS. LPS bound to LBP is a ligand for CD14 which in turn presents LPS to TLR4 by transferring LPS to MD2. LBP plays a dual role, both potentiating and decreasing cell responses to LPS [2]. Low concentrations of LBP enhance cell stimulation, whereas high LBP concentrations inhibit cell responses to LPS. LBP attenuates signal responses by interfering with LPS transfer from CD14 to the TLR4/MD2 receptor complex [3].
1. Schumann RR. et al., 1990. Structure and function of lipopolysaccharide binding protein. Science. 249(4975):1429-31.
2. Gutsmann T. et al., 2001. Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells. Infect Immun. 69(11):6942-50.
3. Thompson PA. et al., 2003. Lipopolysaccharide (LPS)-binding protein inhibits responses to cell-bound LPS. J Biol Chem. 278(31):28367-71.
Specifications
Human LBP (pUNO1-hLBP)
GenBank : NM_004139.4 with silent variations in codons Leu48, Gln99, & Ser204
ORF size : 1446 bp
Subclone : NcoI - NheI
Mouse LBP (pUNO1-mLBP)
ORF size : 1446 bp
Subclone : BspHI - NheI
pUNO1 Contents
- 20 µg of lyophilized DNA
- 2 x 1 ml blasticidin at 10 mg/ml
Product is shipped at room temperature.
Lyophilized DNA should be stored at -20°C. Upon receipt, store blasticidin at 4°C or -20°C.
Resuspended DNA should be stored at -20°C and is stable for up to 1 year.
Blasticidin is a harmful compound. Refer to the safety data sheet for handling instructions.